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Asymmetric cell division during T cell development controls downstream fate
During mammalian T cell development, the requirement for expansion of many individual T cell clones, rather than merely expansion of the entire T cell population, suggests a possible role for asymmetric cell division (ACD). We show that ACD of developing T cells controls cell fate through differential inheritance of cell fate determinants Numb and α-Adaptin. ACD occurs specifically during the β...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2020
ISSN: 1759-5061,1759-507X
DOI: 10.1038/s41581-020-0306-5